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AKUAMMA SEEDS - 250 GRAMS

AKU-250G
$35.00

High quality organic Akuamma Seeds

FREE SHIPPING - USPS - US WAREHOUSE

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The seeds of picralima nitida, known commonly as akuamma seeds, have been traditionally used in west Africa as a traditional herb for pain support. Akuamma seeds come in grapefruit-sized fruits which resemble smooth-skinned varieties of avocado when they’re fully ripe.  Only in the last few years have akuamma seeds started becoming popular in the U.S. as people have searched out new herbal alternatives. But it is still a relatively unknown plant even to most herb enthusiasts.

In certain states where kratom has been prohibited, picralima nitida seeds offer people another natural choice with equally promising results. Akuamma seeds contain a number of alkaloids that act on the opiod receptors. Akuamma can be quite synergistic with kratom since the two herbs have similar activity in the brain. Cross tolerance can occur too, but it can possibly help with short-term tolerance in the same way switching strains can work for some people.

Akuamma does not seem to have different strains in the same way kratom does, although it would be interesting to study the variation in alkaloid profile between different batches of akuamma seeds, or those grown in different conditions. The chief alkaloid present in akuamma seeds is akuammine, which is an indole alkaloid. Indole alkaloids are the largest group of alkaloids, with over 4000 compounds containing what is known as an indole ring structure. A number of important and medicinal compounds such as mitragynine and yohimbine are also indoles. In addition to akuammine, akuamma seeds also contain akuammine, akuammigne, and akuammidine.

An agonist is a compound which shows activity on a certain receptor. An antagonist is a compound which blocks activity on that receptor. It is surprising to note that akuammine is an opiod antagonist. One would not expect that the major alkaloid in an herb sought for pain relief has the opposite effect. But the effects are still possible since the other compounds in akuamma seeds are agonists. You might still expect that a major alkaloid would cancel out minor alkaloids, but that is not the case here. Some also suspect that maybe there is a conversion of akuammine into something else when it enters the body, which could cancel out its antagonist properties.

We offer akuamma in whole seed, powder and extract form. Our seeds are sourced directly from the best African akuamma farms. 

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